Article
Modified heparins inhibit integrin α<sub>IIb</sub>β<sub>3</sub> mediated adhesion of melanoma cells to platelets <i>in vitro</i> and <i>in vivo</i>
11 May 2009
Abstract excerpt
The adhesion of tumor cells with platelets is important in the process of tumor metastasis. A huge work has indicated that anti-adhesion is an effective strategy for metastasis inhibition. In this article, we assess the role of platelet integrin alpha(IIb)beta(3) in adhesion of melanoma cells to platelets and the effects of heparin and modified heparins on the adhesion in vitro and in vivo. We show that platelet...
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