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Article

Microvessel endothelial cells and pericytes increase proliferation and repress osteoblast phenotypic markers in rat calvarial bone cell cultures.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Jul 1995

Jones A R, Clark C C, Brighton C T

Abstract excerpt

To investigate the influence of microvessel cells on osteoblasts, we exposed osteoblast-enriched cultures of rat calvarial cells to cultured endothelial cells and pericytes using feeder-layer co-cultures, co-culture dish inserts, and conditioned media experiments. When co-cultured with growth-arrested feeder-layers of endothelial cells or pericytes for 10 days, bone cell cultures showed an increase in cell number...

Topics

Animals
Cell Communication
Cell Division
Cells, Cultured
Culture Media, Conditioned
Cytological Techniques
Endothelium, Vascular
Genetic Markers
Microcirculation
Osteoblasts

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Rats

Rats, Sprague-Dawley

Skull

Source

Identifiers

PMID: 7674071
DOI: 10.1002/jor.1100130410

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7674071-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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