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Article

Hypoxia regulates VEGF expression and cellular proliferation by osteoblasts in vitro.

Plastic and reconstructive surgery - 1 Sept 1999

Steinbrech D S, Mehrara B J, Saadeh P B, Chin G, Dudziak M E, Gerrets R P, Gittes G K, Longaker M T

Abstract excerpt

Numerous studies have demonstrated the critical role of angiogenesis for successful osteogenesis during endochondral ossification and fracture repair. Vascular endothelial growth factor (VEGF), a potent endothelial cell-specific cytokine, has been shown to be mitogenic and chemotactic for endothelial cells in vitro and angiogenic in many in vivo models. Based on previous work that (1) VEGF is up-regulated during...

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Identifiers

PMID: 10456527
DOI: 10.1097/00006534-199909030-00019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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