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Article

Bone mineralization and osteoblast differentiation are negatively modulated by integrin alpha(v)beta3.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Feb 2001

Cheng S L, Lai C F, Blystone S D, Avioli L V

Abstract excerpt

Numerous bone matrix proteins can interact with alpha(v)-containing integrins including alpha(v)beta3. To elucidate the net effects of the interaction between these proteins and alpha(v)beta3 on osteoblast function, we developed a murine osteoblastic cell line that overexpressed human alpha(v)beta3. Human alpha(v)beta3-integrin was expressed on cell membrane, in which its presence did not alter the surface level...

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Identifiers

PMID: 11204428
DOI: 10.1359/jbmr.2001.16.2.277

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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