Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds.

doi:10.1016/j.biomaterials.2008.09.058

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Article

Contribution of outgrowth endothelial cells from human peripheral blood on in vivo vascularization of bone tissue engineered constructs based on starch polycaprolactone scaffolds.

Biomaterials - 1 Feb 2009

Fuchs Sabine, Ghanaati Shahram, Orth Carina, Barbeck Mike, Kolbe Marlen, Hofmann Alexander, Eblenkamp Markus, Gomes Manuela, Reis Rui L, Kirkpatrick Charles J

Abstract excerpt

In the present study we assessed the potential of human outgrowth endothelial cells (OEC), a subpopulation within endothelial progenitor cell cultures, to support the vascularization of a complex tissue engineered construct for bone. OEC cultured on starch polycaprolactone fiber meshes (SPCL) in monoculture retained their endothelial functionality and responded to angiogenic stimulation by VEGF (vascular...

Topics

Animals
Bone and Bones
Cell Proliferation
Coculture Techniques
Collagen
Drug Combinations
Endothelial Cells
Gene Expression Regulation
Humans
Implants, Experimental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Laminin

Mice

Mice, SCID

Neovascularization, Physiologic

Osteoblasts

Osteogenesis

Phenotype

Polyesters

Source

Open in PubMed

Identifiers

PMID: 18977026
DOI: 10.1016/j.biomaterials.2008.09.058

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