Article
The effect of human osteoblasts on proliferation and neo-vessel formation of human umbilical vein endothelial cells in a long-term 3D co-culture on polyurethane scaffolds.
Biomaterials - 1 Nov 2008
Hofmann Alexander, Ritz Ulrike, Verrier Sophie, Eglin David, Alini Mauro, Fuchs Sabine, Kirkpatrick C James, Rommens Pol Maria
Abstract excerpt
Angiogenesis is a key element in early wound healing and is considered important for tissue regeneration and for directing inflammatory cells to the wound site. The improvement of vascularization by implementation of endothelial cells or angiogenic growth factors may represent a key solution for engineering bone constructs of large size. In this study, we describe a long-term culture environment that supports the...
Topics
- Biomarkers
- Cell Proliferation
- Cells, Cultured
- Coculture Techniques
- Endothelial Cells
- Fluorescent Antibody Technique
- Gene Expression Regulation
- Humans
- Microscopy, Confocal
- Neovascularization, Physiologic