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Article

αvβ Integrins Play an Essential Role in BMP-2 Induction of Osteoblast Differentiation

1 Feb 2005

Abstract excerpt

UNLABELLED: Both integrins and BMP-2 exert similar effects on osteoblasts. We examined the relationship between the alphav-containing integrins (alphavbeta) and BMP-2 in osteoblast function. BMP-2 stimulates alphavbeta expression. BMP-2 receptors co-localize/overlap with alphavbeta integrins, and the intact function of alphavbeta is essential in BMP-2 activity. INTRODUCTION: Bone morphogenetic protein (BMP)-2 not...

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PMID: 15647827
DOI: 10.1359/jbmr.041013

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