Article
Inhibition of MAP2 expression affects both morphological and cell division phenotypes of neuronal differentiation.
Cell - 22 Feb 1991
Dinsmore J H, Solomon F
Abstract excerpt
Expression of the differentiated neuronal phenotype is typically manifest in several properties: distinct morphologies and organizations of the underlying cytoskeleton; appearance of specific macromolecules; and cessation of cell division. All of these properties are induced in undifferentiated embryonal carcinoma cells exposed to retinoic acid. We show here that the mRNA and protein for the microtubule component...
Topics
- Animals
- Antibodies, Monoclonal
- Cell Differentiation
- Cell Division
- Cell Line
- Fluorescent Antibody Technique
- Gene Expression
- Kinetics
- Microtubule-Associated Proteins
- Neurons
- Phenotype