Article
Induction of differentiation and suppression of malignant phenotype of human neuroblastoma BE(2)-C cells by valproic acid: enhancement by combination with interferon-alpha.
International journal of oncology - 1 Jan 2002
Cinatl Jindrich, Kotchetkov Rouslan, Blaheta Roman, Driever Pablo Hernáiz, Vogel Jens Uwe, Cinatl Jaroslav
Abstract excerpt
Valproic acid (VPA) has been shown to induce growth-arrest and differentiation of human neuroectodermal tumors similarly to several other fatty acids. In the present study, we show that continuous VPA treatment together with Interferon-alpha (INF-alpha) synergistically inhibited cell growth of a well-established model of neuroblastoma (NB) differentiation using the human N-myc amplified cell line BE(2)-C....
Topics
- Antineoplastic Agents
- Biomarkers, Tumor
- Brain Neoplasms
- Cell Differentiation
- Cell Division
- DNA Primers
- Drug Synergism
- Drug Therapy, Combination
- Electrophoretic Mobility Shift Assay
- Enzyme Inhibitors
- Enzyme-Linked Immunosorbent Assay
- Flow Cytometry