Article
Positional cloning of the gene for multiple endocrine neoplasia-type 1.
Science (New York, N.Y.) - 18 Apr 1997
Chandrasekharappa S C, Guru S C, Manickam P, Olufemi S E, Collins F S, Emmert-Buck M R, Debelenko L V, Zhuang Z, Lubensky I A, Liotta L A, Crabtree J S, Wang Y, Roe B A, Weisemann J, Boguski M S, Agarwal S K, Kester M B, Kim Y S, Heppner C, Dong Q, Spiegel A M, Burns A L, Marx S J
Abstract excerpt
Multiple endocrine neoplasia-type 1 (MEN1) is an autosomal dominant familial cancer syndrome characterized by tumors in parathyroids, enteropancreatic endocrine tissues, and the anterior pituitary. DNA sequencing from a previously identified minimal interval on chromosome 11q13 identified several...
Topics
- Amino Acid Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Cloning, Molecular
- DNA, Complementary
- Exons
- Frameshift Mutation
- Genes, Tumor Suppressor
- Humans
- Molecular Sequence Data