Article
Mutations of the androgen receptor coding sequence are infrequent in patients with isolated hypospadias.
The Journal of clinical endocrinology and metabolism - 1 Sept 1995
Alléra A, Herbst M A, Griffin J E, Wilson J D, Schweikert H U, McPhaul M J
Abstract excerpt
Androgen receptor defects can cause severe hypospadias. To examine the possibility that androgen receptor defects are a common cause of such deficiencies, we have determined the coding sequence of the androgen receptor gene in nine patients with severe hypospadias. The analysis of the androgen receptor coding sequence predicts a normal amino acid sequence for the androgen receptor of eight of the nine patients,...
Topics
- Base Sequence
- Cholestenone 5 alpha-Reductase
- DNA
- Dihydrotestosterone
- Fibroblasts
- Genitalia, Male
- Humans
- Hypospadias
- Male
- Molecular Sequence Data
- Mutation