Article
Role of the androgen receptor in male sexual differentiation.
Hormone research - 1 Jan 1992
Batch J A, Williams D M, Davies H R, Brown B D, Evans B A, Hughes I A, Patterson M N
Abstract excerpt
The two androgens responsible for all aspects of male sexual differentiation are testosterone and dihydrotestosterone. The action of both these steroids is mediated by a specific intracellular receptor, the androgen receptor, which is a member of the nuclear receptor superfamily. The androgen receptor gene has been cloned and is located on the X chromosome at Xq11-12. Mutations of this gene have been found in...
Topics
- Dihydrotestosterone
- Disorders of Sex Development
- Humans
- Hypospadias
- Male
- Mutation
- Phenotype
- Receptors, Androgen
- Sex Differentiation
- Testosterone