Article
Minor hypospadias: the "tip of the iceberg" of the partial androgen insensitivity syndrome.
PloS one - 1 Jan 2013
Kalfa Nicolas, Philibert Pascal, Werner Ralf, Audran Françoise, Bashamboo Anu, Lehors Hélène, Haddad Myriam, Guys Jean Michel, Reynaud Rachel, Alessandrini Pierre, Wagner Kathy, Kurzenne Jean Yves, Bastiani Florence, Bréaud Jean, Valla Jean Stéphane, Lacombe Gérard Morisson, Orsini Mattea, Daures Jean-Pierre, Hiort Olaf, Paris Françoise, McElreavey Kenneth, Sultan Charles
Abstract excerpt
BACKGROUND: Androgens are critical in male external genital development. Alterations in the androgen sensitivity pathway have been identified in severely undermasculinized boys, and mutations of the androgen receptor gene (AR) are usually found in partial or complete androgen insensitivity syndrome (AIS). OBJECTIVE: The aim of this study was to determine whether even the most minor forms of isolated hypospadias...
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