Androgen resistance caused by mutations in the androgen receptor gene.

Abstract excerpt

Defects in the human androgen receptor cause a spectrum of defects in male phenotypic sexual development associated with abnormalities in the receptor protein assayed in cultured fibroblasts and in broken cell assays. In some patients these abnormalities are associated with absent ligand binding, in other qualitative or quantitative abnormalities of ligand binding are present, and in some no abnormality of ligand...

Topics

• Androgens
• Drug Resistance
• Genes
• Humans
• Mutation
• Receptors, Androgen