Article
Molecular characterization of the androgen receptor gene in boys with hypospadias.
European journal of pediatrics - 1 May 1994
Hiort O, Klauber G, Cendron M, Sinnecker G H, Keim L, Schwinger E, Wolfe H J, Yandell D W
Abstract excerpt
Development of male external genitalia is dependent on androgens, and karyotypic males lacking appropriate levels of androgens or functionally normal receptors may show abnormal virilization. Mutations in the androgen receptor gene cause abnormal receptor function and diverse mutations may be associated with heterogeneous clinical signs of androgen insensitivity. In this study, we have searched for the existence...
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