Article
Mutations of androgen receptor gene in androgen insensitivity syndromes.
The Journal of steroid biochemistry and molecular biology - 1 Nov 1993
Sultan C, Lumbroso S, Poujol N, Belon C, Boudon C, Lobaccaro J M
Abstract excerpt
The androgen receptor belongs to the family of steroid-thyroid hormone-retinoid nuclear receptors. It contains 3 major domains: a hormone-binding region, a DNA-binding region and an amino-terminal region. Cloning of the cDNA encoding the androgen receptor and elucidation of the androgen receptor gene structure enabled the characterization of the molecular defects associated with androgen insensitivity. Mutations...
Topics
- Androgen-Insensitivity Syndrome
- Androgens
- Disorders of Sex Development
- Female
- Gonadal Dysgenesis, 46,XY
- Humans
- Male
- Mutation
- Receptors, Androgen
- Syndrome