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Article

The Grb2 splice variant, Grb3-3, is a negative regulator of RAS activation.

Communications biology - 28 Sept 2022

Seiler Caroline, Stainthorp Amy K, Ketchen Sophie, Jones Christopher M, Marks Kate, Quirke Philip, Ladbury John E

Abstract excerpt

Activation of RAS is crucial in driving cellular outcomes including proliferation, differentiation, migration and apoptosis via the MAPK pathway. This is initiated on recruitment of Grb2, as part of a Grb2-Sos complex, to an up-regulated receptor tyrosine kinase (RTK), enabling subsequent interaction of Sos with the plasma membrane-localised RAS. Aberrant regulation at this convergence point for RTKs in MAPK...

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Identifiers

PMID: 36171279
DOI: 10.1038/s42003-022-03985-7
PMCID: PMC9519967

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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