Article
The transmission/disequilibrium test: history, subdivision, and admixture.
American journal of human genetics - 1 Aug 1995
Ewens W J, Spielman R S
Abstract excerpt
Disease association with a genetic marker is often taken as a preliminary indication of linkage with disease susceptibility. However, population subdivision and admixture may lead to disease association even in the absence of linkage. In a previous paper, we described a test for linkage (and linkage disequilibrium) between a genetic marker and disease susceptibility; linkage is detected by this test only if...
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