The transmission/disequilibrium test: history, subdivision, and admixture.

Article

The transmission/disequilibrium test: history, subdivision, and admixture.

American journal of human genetics - 1 Aug 1995

Ewens W J, Spielman R S

Abstract excerpt

Disease association with a genetic marker is often taken as a preliminary indication of linkage with disease susceptibility. However, population subdivision and admixture may lead to disease association even in the absence of linkage. In a previous paper, we described a test for linkage (and link...

Topics

Alleles
Genetic Diseases, Inborn
Humans
Linkage Disequilibrium
Models, Genetic
Models, Statistical

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