Article
Impact of population structure, effective bottleneck time, and allele frequency on linkage disequilibrium maps.
Proceedings of the National Academy of Sciences of the United States of America - 28 Dec 2004
Zhang Weihua, Collins Andrew, Gibson Jane, Tapper William J, Hunt Sarah, Deloukas Panos, Bentley David R, Morton Newton E
Abstract excerpt
Genetic maps in linkage disequilibrium (LD) units play the same role for association mapping as maps in centimorgans provide at much lower resolution for linkage mapping. Association mapping of genes determining disease susceptibility and other phenotypes is based on the theory of LD, here applied to relations with three phenomena. To test the theory, markers at high density along a 10-Mb continuous segment of...
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