Article
Impact of the ultrarapid metabolizer genotype of cytochrome P450 2D6 on metoprolol pharmacokinetics and pharmacodynamics.
Clinical pharmacology and therapeutics - 1 Oct 2004
Kirchheiner Julia, Heesch Claudia, Bauer Steffen, Meisel Christian, Seringer Angela, Goldammer Mark, Tzvetkov Mladen, Meineke Ingolf, Roots Ivar, Brockmöller Jürgen
Abstract excerpt
INTRODUCTION: In the treatment of heart failure and hypertension with metoprolol, ultrarapid metabolizers (UMs) may not achieve optimal target concentrations with recommended doses. We compared metoprolol pharmacokinetics and effects in UMs with extensive metabolizers (EMs) and with poor metabolizers (PM) as an additional reference group. METHODS: After a single dose of 100 mg metoprolol, pharmacokinetics,...
Topics
- Administration, Oral
- Adrenergic beta-Antagonists
- Adult
- Alleles
- Area Under Curve
- Blood Pressure
- Cytochrome P-450 CYP2D6
- Exercise Test
- Female
- Genotype
- Heart Rate
- Humans
- Male