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Article

LKB1 (XEEK1) regulates Wnt signalling in vertebrate development.

Nature cell biology - 1 Oct 2003

Ossipova Olga, Bardeesy Nabeel, DePinho Ronald A, Green Jeremy B A

Abstract excerpt

Germline LKB1/STK11 mutations are associated with the cancer-prone Peutz-Jeghers syndrome (PJS) in humans, and nullizygosity provokes a poorly understood constellation of developmental perturbations in the mid-gestational mouse. To gain a better understanding of the processes regulated by LKB1, we have exploited the experimental merits of the developing Xenopus embryo. Here, specific inhibition of XEEK1, the...

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Source

Identifiers

PMID: 12973359
DOI: 10.1038/ncb1048

Genes

STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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