Article
A subset of p53-deficient embryos exhibit exencephaly.
Nature genetics - 1 Jun 1995
Sah V P, Attardi L D, Mulligan G J, Williams B O, Bronson R T, Jacks T
Abstract excerpt
Defects in neural tube formation are among the most common malformations leading to infant mortality. Although numerous genetic loci appear to contribute to the defects observed in humans and in animal model systems, few of the genes involved have been characterized at the molecular level. Mice lacking the p53 tumour suppressor gene are predisposed to tumours, but the viability of these animals indicates that p53...
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