Article
Exencephaly in a subset of animals heterozygous for AP-2alpha mutation.
Teratology - 1 May 2002
Kohlbecker Andreas, Lee Anna E, Schorle Hubert
Abstract excerpt
BACKGROUND: Transcription factor AP-2alpha has been implicated as a cell-type-specific regulator of gene expression during vertebrate embryogenesis based on its expression pattern in neural crest cells, ectoderm, and the nervous system in mouse, chick, and frog embryos. AP-2alpha is prominently expressed in cranial neural crest cells, a population of cells migrating from the lateral margins of the neural folds...
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