Article
Embryogenesis of holoprosencephaly.
American journal of medical genetics. Part A - 15 Dec 2007
Shiota Kohei, Yamada Shigehito, Komada Munekazu, Ishibashi Makoto
Abstract excerpt
Holoprosencephaly (HPE) is a malformation of the human brain caused primarily by incomplete division of the prosencephalon into two halves and is often associated with various facial anomalies. Although HPE is rather rare in newborns (1/10,000-15,000 births), it is frequently encountered in therapeutic abortuses (>1/250). To date, nine gene mutations responsible for human HPE have been identified, but the...
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