Genetic modifiers interact with Cpe(fat) to affect body weight, adiposity, and hyperglycemia.

doi:10.1152/physiolgenomics.00208.2003

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Article

Genetic modifiers interact with Cpe(fat) to affect body weight, adiposity, and hyperglycemia.

Physiological genomics - 14 Jul 2005

Collin Gayle B, Maddatu Terry P, Sen Saunak, Naggert Jürgen K

Abstract excerpt

Obesity and Type II diabetes are complex diseases in the human population. The existence of a large number of contributing loci and gene-gene as well as gene-environment interactions make it difficult to identify the disease genes underlying these complex traits. In mouse models of obesity and Type II diabetes such as the murine fat mutation, genetic crosses can be used to dissect the genetic complexity...

Topics

Adiposity
Analysis of Variance
Animals
Blood Glucose
Body Weight
Carboxypeptidase H
Chromosome Segregation
Crosses, Genetic
Disease Models, Animal
Genetic Testing
Genome
Hyperglycemia
Hyperinsulinism
Hyperlipidemias
Male
Mice
Phenotype
Quantitative Trait Loci

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Open in PubMed

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PMID: 15870393
DOI: 10.1152/physiolgenomics.00208.2003

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