Article
Effects of striatal excitotoxicity on huntingtin-like immunoreactivity.
Neuroreport - 30 May 1995
Tatter S B, Galpern W R, Hoogeveen A T, Isacson O
Abstract excerpt
The relationship between the specific neuronal loss observed in Huntington's disease and the mutation in the IT15 gene responsible for this disease remains obscure. Using an antipeptide antibody against amino acids 3114-3141 of the human huntington protein, we demonstrate that striatal injection of quinolinic acid in mice induces increased immunoreactivity for huntington in some remaining neurons but not in glial...
Topics
- Animals
- Antibodies
- Cell Death
- Corpus Striatum
- Excitatory Amino Acids
- Gene Expression
- Huntingtin Protein
- Huntington Disease
- Immunohistochemistry
- Male
- Mice
- Mice, Inbred Strains