Article
Calcineurin is involved in the early activation of NMDA-mediated cell death in mutant huntingtin knock-in striatal cells.
Journal of neurochemistry - 1 Jun 2008
Xifró Xavier, García-Martínez Juan Manuel, Del Toro Daniel, Alberch Jordi, Pérez-Navarro Esther
Abstract excerpt
Excitotoxicity has been proposed as one of the mechanisms involved in the specific loss of striatal neurons that occurs in Huntington's disease. Here, we studied the role of calcineurin in the vulnerability of striatal neurons expressing mutant huntingtin to excitotoxicity. To this end, we induced excitotoxicity by adding NMDA to a striatal precursor cell line expressing full-length wild-type (STHdh(Q7/Q7)) or...
Topics
- Animals
- Calcineurin
- Cell Death
- Cell Line, Transformed
- Cell Survival
- Cells, Cultured
- Corpus Striatum
- Huntingtin Protein
- Huntington Disease
- Mice
- Mice, Inbred C57BL
- Mutation
- N-Methylaspartate
- Nerve Tissue Proteins
- Nuclear Proteins