Article
Expression of cartilage-specific molecules is retained on long-term culture of human articular chondrocytes.
Journal of cell science - 1 May 1995
Kolettas E, Buluwela L, Bayliss M T, Muir H I
Abstract excerpt
Normal human adult articular chondrocytes were used to determine how the chondrocyte phenotype is modulated by culture conditions following long-term culture. We report here for the first time that human articular chondrocytes have a lifespan in the range of 34-37 population doublings. While chon...
Topics
- Adult
- Base Sequence
- Biomarkers
- Cartilage, Articular
- Cell Differentiation
- Cell Division
- Cells, Cultured
- Child
- Collagen
- Extracellular Matrix Proteins
- Female
- Gene Expression
- Humans
- Molecular Sequence Data
- Phenotype
- Protein Biosynthesis
- Proteins
- Proteoglycans