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Article

Phenotypic stability of articular chondrocytes in vitro: the effects of culture models, bone morphogenetic protein 2, and serum supplementation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2000

Stewart M C, Saunders K M, Burton-Wurster N, Macleod J N

Abstract excerpt

Numerous in vitro culture models have been developed for the investigation of chondrocyte and cartilage biology. In this study, we investigated the stability of the chondrocytic phenotype in monolayer, aggregate, pellet, and explant culture models and assessed the effects of recombinant human bone morphogenetic protein 2 (rhBMP-2) and serum supplementation on the phenotype in each model. Phenotypic effects were...

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Identifiers

PMID: 10646126
DOI: 10.1359/jbmr.2000.15.1.166

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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