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Article

Immortalized human adult articular chondrocytes maintain cartilage-specific phenotype and responses to interleukin-1beta.

Arthritis and rheumatism - 1 Oct 2000

Robbins J R, Thomas B, Tan L, Choy B, Arbiser J L, Berenbaum F, Goldring M B

Abstract excerpt

OBJECTIVE: To develop a reproducible immortalized human chondrocyte culture model for studying the regulation of chondrocyte functions relevant to arthritic diseases in adult humans. METHODS: Primary adult articular chondrocytes were immortalized with a retrovirus expressing a temperature-sensitive mutant of SV40-large T antigen (tsTAg). The established tsT/AC62 chondrocyte cell line was examined in monolayer and...

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PMID: 11037878
DOI: 10.1002/1529-0131(200010)43:10<2189::AID-ANR6>3.0.CO;2-S

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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