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Article

Increased life span of human osteoarthritic chondrocytes by exogenous expression of telomerase

1 Mar 2002

Abstract excerpt

OBJECTIVE: To extend the life span of human osteoarthritic (OA) articular chondrocytes by introduction of the catalytic component of human telomerase while preserving the chondrocyte-specific phenotype. METHODS: Human articular chondrocytes were isolated from the femoral head and tibial plateau of patients undergoing knee joint replacement for OA. The chondrocytes were cultured as monolayers and infected with a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 11920404
DOI: 10.1002/art.10116

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