Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter.

doi:10.1111/j.1399-0039.1995.tb02460.x

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Article

Early-onset pauciarticular juvenile chronic arthritis is associated with a mutation in the Y-box of the HLA-DQA1 promoter.

Tissue antigens - 1 May 1995

Haas J P, Kimura A, Truckenbrodt H, Suschke J, Sasazuki T, Volgger A, Albert E D

Abstract excerpt

Early-onset pauciarticular juvenile chronic arthritis (EOPA-JCA) has associations with different alleles of the MHC region (HLA-A2, DR5, 6, 8, DQA1*0401, *0501, *0601 and DPB1*0201). All susceptible DQA1 alleles carry an exclusive sequence motif. MHC-class II gene expression is controlled by 5' f...

Topics

Age of Onset
Alleles
Arthritis, Juvenile
Base Sequence
HLA-DQ Antigens
HLA-DQ alpha-Chains
Humans
Molecular Sequence Data
Mutation
Promoter Regions, Genetic

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