Article
A model for the role of HLA-DQ molecules in the pathogenesis of juvenile chronic arthritis.
Rheumatology international - 1 Jan 1991
Haas J P, Andreas A, Rutkowski B, Brunner H, Keller E, Hoza J, Havelka S, Sierp G, Albert E D
Abstract excerpt
Restriction fragment length polymorphism (RFLP) typing of MHC-class II loci DRB, DQA1, DQB1, DQA2 and DPB1 was performed in 94 patients with seronegative juvenile chronic arthritis (JCA) and 184 random controls. Analysis of allele frequencies and MHC-class II 4-loci haplotypes indicate: (1) Susceptibility to JCA is more strongly associated with the HLA-DQ subregion than with the HLA-DR subregion, especially in...
Topics
- Alleles
- Amino Acid Sequence
- Arthritis, Juvenile
- Child
- Disease Susceptibility
- HLA-DQ Antigens
- Humans
- Molecular Sequence Data
- Polymorphism, Genetic
- Polymorphism, Restriction Fragment Length