Article
A model for the role of HLA-DQ molecules in the pathogenesis of juvenile chronic arthritis.
Rheumatology international - 1 Jan 1991
Haas J P, Andreas A, Rutkowski B, Brunner H, Keller E, Hoza J, Havelka S, Sierp G, Albert E D
Abstract excerpt
Restriction fragment length polymorphism (RFLP) typing of MHC-class II loci DRB, DQA1, DQB1, DQA2 and DPB1 was performed in 94 patients with seronegative juvenile chronic arthritis (JCA) and 184 random controls. Analysis of allele frequencies and MHC-class II 4-loci haplotypes indicate: (1) Susceptibility to JCA is more strongly associated with the HLA-DQ subregion than with the HLA-DR subregion, especially in...
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