Amplification of <i>Mdmx</i> (or <i>Mdm4</i>) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

Abstract excerpt

Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or through aberrant expression of proteins acting in the p53 pathway, such as p14(ARF) or Mdm2. A role for Mdmx (or Mdm4) as a key negative regulator of p53 function in vivo has been established. However, a direct contribution of Mdmx to tumor formation remains to be demonstrated. Here we...

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