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Article

Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface.

Nature - 31 Aug 1995

Yu H, Schreiber S L

Abstract excerpt

Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4), has been identified. Here we use multidimensional NMR to determine the structure of human Mss4...

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PMID: 7651540
DOI: 10.1038/376788a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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