Article
Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface.
Nature - 31 Aug 1995
Yu H, Schreiber S L
Abstract excerpt
Guanine-nucleotide-exchange factors (GEFs) promote the exchange of GDP for GTP in Ras GTPases, and thereby positively regulate their functions. Members of the Sec4/Ypt1/Rab branch of the Ras superfamily are essential for vesicular transport. A GEF for a subset of Rab proteins, termed mammalian suppressor of Sec4 (Mss4), has been identified. Here we use multidimensional NMR to determine the structure of human Mss4...
Topics
- Amino Acid Sequence
- Binding Sites
- GTP-Binding Proteins
- Guanine Nucleotide Exchange Factors
- Humans
- Molecular Sequence Data
- Mutation
- Protein Binding
- Protein Structure, Tertiary
- Proteins
- Surface Properties