Identification and characterisation of novel Mss4-binding Rab GTPases.

doi:10.1515/BC.2011.022

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Article

Identification and characterisation of novel Mss4-binding Rab GTPases.

Biological chemistry - 1 Mar 2011

Wixler Viktor, Wixler Ludmilla, Altenfeld Anika, Ludwig Stephan, Goody Roger S, Itzen Aymelt

Abstract excerpt

The Mss4 (mammalian suppressor of yeast Sec4) is an evolutionarily highly conserved protein and is expressed in all mammalian tissues. Although its precise biological function is still elusive, it has been shown to associate with a subset of secretory Rab proteins (Rab1b, Rab3a, Rab8a, Rab10) and to possess a rather low guanine nucleotide exchange factor (GEF) activity towards them in vitro (Rab1, Rab3a and...

Topics

Amino Acid Sequence
Animals
Fluorescent Antibody Technique
Guanine Nucleotide Exchange Factors
HEK293 Cells
Humans
Mice
Molecular Chaperones
Molecular Sequence Data
Mutation
NIH 3T3 Cells
Protein Binding
rab GTP-Binding Proteins

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Identifiers

PMID: 21194374
DOI: 10.1515/BC.2011.022

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