Article
Identification and characterisation of novel Mss4-binding Rab GTPases.
Biological chemistry - 1 Mar 2011
Wixler Viktor, Wixler Ludmilla, Altenfeld Anika, Ludwig Stephan, Goody Roger S, Itzen Aymelt
Abstract excerpt
The Mss4 (mammalian suppressor of yeast Sec4) is an evolutionarily highly conserved protein and is expressed in all mammalian tissues. Although its precise biological function is still elusive, it has been shown to associate with a subset of secretory Rab proteins (Rab1b, Rab3a, Rab8a, Rab10) and to possess a rather low guanine nucleotide exchange factor (GEF) activity towards them in vitro (Rab1, Rab3a and...
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