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Article

Crystal and solution structure of NDRG1, a membrane-binding protein linked to myelination and tumour suppression.

The FEBS journal - 1 Jun 2021

Mustonen Venla, Muruganandam Gopinath, Loris Remy, Kursula Petri, Ruskamo Salla

Abstract excerpt

N-myc downstream-regulated gene 1 (NDRG1) is a tumour suppressor involved in vesicular trafficking and stress response. NDRG1 participates in peripheral nerve myelination, and mutations in the NDRG1 gene lead to Charcot-Marie-Tooth neuropathy. The 43-kDa NDRG1 is considered as an inactive member of the α/β hydrolase superfamily. In addition to a central α/β hydrolase fold domain, NDRG1 consists of a short N...

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PMID: 33305529
DOI: 10.1111/febs.15660

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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