Article
The genetic diversity within the 1.4 kb HLA-G 5' upstream regulatory region moderately impacts on cellular microenvironment responses.
Scientific reports - 4 Apr 2018
Dias Fabrício C, Bertol Bruna C, Poras Isabelle, Souto Bruno M, Mendes-Junior Celso T, Castelli Erick C, Gineau Laure, Sabbagh Audrey, Rouas-Freiss Nathalie, Carosella Edgardo D, Donadi Eduardo A, Moreau Philippe
Abstract excerpt
The HLA-G 5'URR extending 1.4 kb from the ATG presents a unique set of regulatory elements among HLA genes. Several variable sites have been described that coincide with or are close to these elements, thus HLA-G 5'URR polymorphism might influence the HLA-G expression level. We cloned the ten most frequent HLA-G 5'URR haplotypes to evaluate their activity on a luciferase reporter gene in HLA-G+ cell lines...
Topics
- 5' Untranslated Regions
- Adult
- Cellular Microenvironment
- Choriocarcinoma
- Female
- Genotype
- HLA-G Antigens
- Haplotypes
- Humans
- Male
- Melanoma
- Polymorphism, Single Nucleotide
- Regulatory Sequences, Nucleic Acid