Disruption of Glucocorticoid Action on CD11c+ Dendritic Cells Favors the Generation of CD4+ Regulatory T Cells and Improves Fetal Development in Mice.

doi:10.3389/fimmu.2021.729742

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Article

Disruption of Glucocorticoid Action on CD11c+ Dendritic Cells Favors the Generation of CD4+ Regulatory T Cells and Improves Fetal Development in Mice.

Frontiers in immunology - 1 Jan 2021

Diao Lianghui, Hierweger Alexandra Maximiliane, Wieczorek Agnes, Arck Petra Clara, Thiele Kristin

Abstract excerpt

A wealth of innate and adaptive immune cells and hormones are involved in mounting tolerance towards the fetus, a key aspect of successful reproduction. We could recently show that the specific cross talk between the pregnancy hormone progesterone and dendritic cells (DCs) is significantly engaged in the generation of CD4+ FoxP3+ regulatory T (Treg) cells while a disruption led to placental alterations and...

Topics

Animals
CD11 Antigens
Dendritic Cells
Female
Fetal Development
Fetal Weight
Fetus
Gestational Age
Glucocorticoids
Histocompatibility, Maternal-Fetal
Immune Tolerance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice, Inbred BALB C

Mice, Inbred C57BL

Mice, Knockout

Phenotype

Placentation

Pregnancy

Source

Open in PubMed Open full text

Identifiers

PMID: 34764952
DOI: 10.3389/fimmu.2021.729742
PMCID: PMC8576435

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