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Article

Sterigmatocystin biosynthesis in Aspergillus nidulans requires a novel type I polyketide synthase

1 Aug 1995

Abstract excerpt

A filamentous fungus, Aspergillus nidulans, produces the carcinogenic mycotoxin sterigmatocystin (ST), which is a polyketide-derived secondary metabolite. A gene (pksST) encoding the ST polyketide synthase (PKSst) in A. nidulans was cloned, sequenced, and characterized. Large induced deletion mutants, which did not make ST or any ST intermediates, were used to identify genes associated with ST biosynthesis. Among...

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PMID: 7642507
DOI: 10.1128/jb.177.16.4792-4800.1995

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