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Article

A genome-wide polyketide synthase deletion library uncovers novel genetic links to polyketides and meroterpenoids in Aspergillus nidulans.

FEMS microbiology letters - 1 Aug 2011

Nielsen Michael L, Nielsen Jakob B, Rank Christian, Klejnstrup Marie L, Holm Dorte K, Brogaard Katrine H, Hansen Bjarne G, Frisvad Jens C, Larsen Thomas O, Mortensen Uffe H

Abstract excerpt

Fungi possess an advanced secondary metabolism that is regulated and coordinated in a complex manner depending on environmental challenges. To understand this complexity, a holistic approach is necessary. We initiated such an analysis in the important model fungus Aspergillus nidulans by systematically deleting all 32 individual genes encoding polyketide synthases. Wild-type and all mutant strains were challenged...

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PMID: 21658102
DOI: 10.1111/j.1574-6968.2011.02327.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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