Article
A polyketide synthase gene required for ochratoxin A biosynthesis in Aspergillus ochraceus.
Microbiology (Reading, England) - 1 Dec 2003
O'Callaghan J, Caddick M X, Dobson A D W
Abstract excerpt
Ochratoxin A is an important nephrotoxic and nephrocarcinogenic mycotoxin, produced by Aspergillus ochraceus as a polyketide-derived secondary metabolite. A portion of a putative polyketide synthase gene (pks) involved in the biosynthesis of this mycotoxin was cloned by using a suppression subtractive hybridization PCR-based approach. The predicted amino acid sequence of the 1.4 kb clone shared 28-35 % identity...
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