Article
Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene.
Nature - 31 Aug 1995
Rogaev E I, Sherrington R, Rogaeva E A, Levesque G, Ikeda M, Liang Y, Chi H, Lin C, Holman K, Tsuda T
Abstract excerpt
We report the cloning of a novel gene (E5-1) encoded on chromosome 1 which has substantial nucleotide and amino-acid sequence similarity to the S182 gene on chromosome 14q24.3. Mutations, including three new missense mutations in the S182 gene, are associated with the AD3 subtype of early-onset f...
Topics
- Alzheimer Disease
- Amino Acid Sequence
- Base Sequence
- Chromosomes, Human, Pair 1
- DNA
- Humans
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Presenilin-1
- Presenilin-2
- Sequence Homology, Amino Acid