Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.

doi:10.1016/0304-3940(94)90463-4

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Article

Amyloid precursor protein mutation causes Alzheimer's disease in a Swedish family.

Neuroscience letters - 28 Feb 1994

Lannfelt L, Bogdanovic N, Appelgren H, Axelman K, Lilius L, Hansson G, Schenk D, Hardy J, Winblad B

Abstract excerpt

Since the report of a double mutation at codons 670 and 671 of the amyloid precursor protein (APP) gene identified in two Swedish families with clinically diagnosed Alzheimer's disease (AD), a carrier with dementia has died. Neuropathology confirmed the clinical diagnosis of AD. Genealogical inve...

Topics

Aged
Alzheimer Disease
Amyloid beta-Protein Precursor
Brain
Female
Genetic Carrier Screening
Genetic Linkage
Humans
Lod Score
Male
Middle Aged
Mutation
Neurofibrillary Tangles
Organ Specificity
Sweden

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