Article
Clinical features of early onset, familial Alzheimer's disease linked to chromosome 14.
American journal of medical genetics - 27 Feb 1995
Mullan M, Bennett C, Figueredo C, Hughes D, Mant R, Owen M, Warren A, McInnis M, Marshall A, Lantos P
Abstract excerpt
Early onset familial Alzheimer's disease (AD) has an autosomal dominant mode of inheritance. Two genes are responsible for the majority of cases of this subtype of AD. Mutations in the beta-amyloid precursor protein (beta APP) gene on chromosome 21 have been shown to completely cosegregate with t...
Topics
- Adult
- Age of Onset
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Chromosomes, Human, Pair 14
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Lod Score
- Male
- Middle Aged
- Mutation
- Pedigree