Article
Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation.
The Journal of clinical investigation - 1 Aug 1995
Boisvert W A, Spangenberg J, Curtiss L K
Abstract excerpt
Apo E, a key regulator of cholesterol-rich lipoprotein metabolism, is synthesized by numerous extrahepatic tissues. Although its synthesis in macrophages is documented, the contribution of macrophage-derived apo E to hepatic clearance of serum cholesterol is unknown. To address this issue bone ma...
Topics
- Alleles
- Animals
- Apolipoproteins E
- Arteriosclerosis
- Base Sequence
- Bone Marrow Transplantation
- Cholesterol
- Diet, Atherogenic
- Gene Transfer Techniques
- Genetic Therapy
- Hyperlipoproteinemia Type II
- Macrophages
- Mice
- Mice, Inbred C57BL
- Molecular Sequence Data
- Organ Specificity
- Polymerase Chain Reaction
- RNA, Messenger