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Article

Treatment of severe hypercholesterolemia in apolipoprotein E-deficient mice by bone marrow transplantation.

The Journal of clinical investigation - 1 Aug 1995

Boisvert W A, Spangenberg J, Curtiss L K

Abstract excerpt

Apo E, a key regulator of cholesterol-rich lipoprotein metabolism, is synthesized by numerous extrahepatic tissues. Although its synthesis in macrophages is documented, the contribution of macrophage-derived apo E to hepatic clearance of serum cholesterol is unknown. To address this issue bone marrow transplantation was performed on hypercholesterolemic apo E-deficient mice with either syngeneic apo E-deficient...

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Identifiers

PMID: 7635947
DOI: 10.1172/JCI118098
PMCID: PMC185301

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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