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Article

Therapeutic liver repopulation in a mouse model of hypercholesterolemia.

Human molecular genetics - 1 Jul 2000

Mitchell C, Mignon A, Guidotti J E, Besnard S, Fabre M, Duverger N, Parlier D, Tedgui A, Kahn A, Gilgenkrantz H

Abstract excerpt

Liver repopulation constitutes an attractive approach for the treatment of liver disorders or of diseases requiring abundant secretion of an active protein. We have described previously a model of selective repopulation of a normal liver by Fas/CD95-resistant hepatocytes, in which we achieved up to 16% hepatocyte repopulation. In the present study, we investigated the therapeutic efficacy of this strategy. With...

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Identifiers

PMID: 10861286
DOI: 10.1093/hmg/9.11.1597

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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