Article
Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse.
Atherosclerosis - 1 Feb 2014
Okutsu Mitsuharu, Lira Vitor A, Higashida Kazuhiko, Peake Jonathan, Higuchi Mitsuru, Suzuki Katsuhiko
Abstract excerpt
Chronic stress is an important risk factor for atherosclerosis, which is a chief process in the development of cardiovascular disease. Increased circulating levels of corticosterone have been documented in several animal models of chronic stress. However, it remains to be established whether corticosterone is sufficient to exacerbate atherosclerosis. To test this hypothesis, apolipoprotein E (ApoE)-deficient mice...
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