Article
Inversions with deletions and duplications.
Genetics - 1 May 1995
Gordon A J, Halliday J A
Abstract excerpt
Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back into the leading-strand template...
Topics
- Base Sequence
- Chromosome Inversion
- DNA Replication
- DNA, Bacterial
- DNA, Single-Stranded
- Escherichia coli
- Gene Deletion
- Models, Genetic
- Molecular Sequence Data
- Multigene Family
- Mutation
- Sequence Homology, Nucleic Acid