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Article

Complex gene rearrangements caused by serial replication slippage.

Human mutation - 1 Aug 2005

Chen Jian-Min, Chuzhanova Nadia, Stenson Peter D, Férec Claude, Cooper David N

Abstract excerpt

The now-classical model of replication slippage can in principle account for both simple deletions and tandem duplications associated with short direct repeats. Invariably, a single replication slippage event is invoked, irrespective of whether simple deletions or tandem duplications are involved. However, we recently identified three complex duplicational insertions that could also be accounted for by a model of...

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Identifiers

PMID: 15977178
DOI: 10.1002/humu.20202

Genes

MECP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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